Moesin stiffens up mitosis
نویسندگان
چکیده
منابع مشابه
Mitosis: Moesin and the Importance of Being Round
Ezrin/radixin/moesin proteins link the actin cytoskeleton to the plasma membrane. Two new reports have found that moesin phosphorylation is essential for mitotic cell rounding and identify a new role for cell rounding in spindle assembly.
متن کاملMolecular networks linked by Moesin drive remodeling of the cell cortex during mitosis
The cortical mechanisms that drive the series of mitotic cell shape transformations remain elusive. In this paper, we identify two novel networks that collectively control the dynamic reorganization of the mitotic cortex. We demonstrate that Moesin, an actin/membrane linker, integrates these two networks to synergize the cortical forces that drive mitotic cell shape transformations. We find tha...
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BACKGROUND During mitosis, animal cells undergo a complex sequence of morphological changes, from retraction of the cell margin and cell rounding at the onset of mitosis to axial elongation and cytokinesis at mitotic exit. The molecular mechanisms driving the early changes in mitotic cell form and their functional significance, however, remain unknown. Here we identify Moesin as a key player. M...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2008
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb0308-258